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Miller is a vitreo-retinal surgeon in the Ophthalmology Department's Retina Service, located at Mass. Eye and Ear's main campus on Charles Street.

She is the chief of service at Mass. Eye and Ear as well as at Mass. General Hospital, chair of the Harvard Medical School Department of Ophthalmology, and director of the Mass. Eye and Ear Angiogenesis Laboratory. A graduate of Massachusetts Institute of Technology and Harvard Medical School, she completed her Ophthalmology residency and Retina fellowship training at Mass.

A member of the full time faculty of Harvard Medical School, Dr. Miller is the David Glendenning Cogan Professor of Ophthalmology.Dr. Miller's clinical and research interests focus on age-related macular degeneration and diabetic retinopathy. She and her colleagues at Mass.

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Eye and Ear pioneered the development of novel therapies that were able to reduce, slow and, in some cases, reverse vision loss in patients.An internationally recognized expert in the field of macular degeneration, Dr. Miller has published more than 100 peer-reviewed papers, 45 book chapters and review articles, is co-editor of Albert and Jakobiec's Principles and Practice of Ophthalmology, and is a named inventor on six U.S. She has received numerous awards from professional and research associations. Miller is Chair of Harvard Ophthalmology, Chief of Ophthalmology at Mass.

Eye and Ear and Mass General Hospital, and Ophthalmologist-in-Chief at Brigham and Women’s Hospital. She also co-directs the Angiogenesis Laboratory, Laser Research Laboratory, and Retina Research Institute at Mass. Eye and Ear.Dr. Miller’s clinical and research interests focus on retinal disorders, including age related macular degeneration (AMD), diabetic eye disease, and macular telangiectasia (MacTel). She and her colleagues at Mass. Eye and Ear pioneered the development of photodynamic therapy (PDT) using verteporfin (Visudyne®), the first pharmacologic therapy for AMD. Miller also identified the role of vascular endothelial growth factor (VEGF) in ocular neovascularization, forming the scientific basis of current antiangiogenic therapies for intraocular vascular diseases (including neovascular AMD and diabetic eye disease).

Miller continues investigations to elucidate the pathophysiology of vision loss and improve therapies for retinal diseases.